PIPGEN - PhD Project 4: Understanding vascular malformations in PHTS.

PIPGEN - PhD Project 4: Understanding vascular malformations in PHTS.

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RESEARCH PROFILE: First Stage Researcher (R1[1])

APPLICATION DEADLINE: 27 June 2021

EU RESEARCH FRAMEWORK PROGRAME: HORIZON 2020

MARIE SKOLODOWSKA CURIE GRANT AGREEMENT NUMBER: 955534

[1] First Stage Researcher (R1) PhD candidate or equivalent. Early stage researcher with less than 4 years FTE research experience.

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PhD Project details

 

30% of the patients with PHTS suffer from vascular malformations. Yet, this clinical condition has been under investigated in PHTS patients. ESR4 will: establish endothelial and epithelial cell models of the disease by introducing PTEN mutations and characterise their functional effects, cellular phenotyes and genetic instability. Primary endothelial cells derived from PHTS patients will be isolated, an in vivo model of the disease using a transgenic mouse model will be generated, combining a germline heterozygous background with a second PTEN hit under the control of a vascular-specific promoter, and the models will be screened for corrective treatments in FDA-approved drug screen. Biology and preclinical insight of these PHTS-derived vascular malformations models will be cross-compared with PHTS-derived epithelial tumours.

Host: Institut de Recerca contra la Leucèmia Josep Carreras (Josep Carreras Institute), Spain.

Supervisor: Dr. Sandra Castillo.

Doctoral programme: University of Barcelona.

Envisioned secondments: Radboudumc, U-Paris. 

 

 

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