PIPGEN - PhD Project 6: Studying T cell exhaustion in a model of APDS.

PIPGEN - PhD Project 6: Studying T cell exhaustion in a model of APDS.

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RESEARCH PROFILE: First Stage Researcher (R1[1])

APPLICATION DEADLINE: 27 June 2021

EU RESEARCH FRAMEWORK PROGRAME: HORIZON 2020

MARIE SKOLODOWSKA CURIE GRANT AGREEMENT NUMBER: 955534

[1] First Stage Researcher (R1) PhD candidate or equivalent. Early stage researcher with less than 4 years FTE research experience.

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PhD Project details

 

Patients with APDS experience T cell exhaustion in response to chronic activation by herpes family viruses. Similarly, mice with an activated PI3Kd mutation raise highly effective immune responses to acute viral infections, but preliminary data show they fail to control chronic infections effectively. We will generate proteomic data sets of T cells obtained from infected mice and map PI3Kd-dependent changes. Candidate genes responsible for T cell exhaustion in a PI3Kd-dependent manner will be CRISPR out  to determine the mechanisms of T cell exhaustion. Pharmacological strategies to reverse T cell exhaustion will be explored.

Host: University of Cambridge (UCAM), UK.

Supervisor: Klaus Okkenhaug.

Doctoral programme: University of Cambridge.

Envisioned secondments: Amstersdam UMC, KITHER.

 

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