PIPGEN - PhD Project 6: Studying T cell exhaustion in a model of APDS.
Research · University of Cambridge > UK
RESEARCH PROFILE: First Stage Researcher (R1)
APPLICATION DEADLINE: 27 June 2021
EU RESEARCH FRAMEWORK PROGRAME: HORIZON 2020
MARIE SKOLODOWSKA CURIE GRANT AGREEMENT NUMBER: 955534
 First Stage Researcher (R1) PhD candidate or equivalent. Early stage researcher with less than 4 years FTE research experience.
PhD Project details
Patients with APDS experience T cell exhaustion in response to chronic activation by herpes family viruses. Similarly, mice with an activated PI3Kd mutation raise highly effective immune responses to acute viral infections, but preliminary data show they fail to control chronic infections effectively. We will generate proteomic data sets of T cells obtained from infected mice and map PI3Kd-dependent changes. Candidate genes responsible for T cell exhaustion in a PI3Kd-dependent manner will be CRISPR out to determine the mechanisms of T cell exhaustion. Pharmacological strategies to reverse T cell exhaustion will be explored.
Host: University of Cambridge (UCAM), UK.
Supervisor: Klaus Okkenhaug.
Doctoral programme: University of Cambridge.
Envisioned secondments: Amstersdam UMC, KITHER.