PIPGEN - PhD Project 7: Role of PTEN/PI3K mutations in increased risk for autism spectrum disorder (ASD).

PIPGEN - PhD Project 7: Role of PTEN/PI3K mutations in increased risk for autism spectrum disorder (ASD).

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RESEARCH PROFILE: First Stage Researcher (R1[1])

APPLICATION DEADLINE: 27 June 2021

EU RESEARCH FRAMEWORK PROGRAME: HORIZON 2020

MARIE SKOLODOWSKA CURIE GRANT AGREEMENT NUMBER: 955534

[1] First Stage Researcher (R1) PhD candidate or equivalent. Early stage researcher with less than 4 years FTE research experience.

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PhD Project details

 

Mutations in the PTEN and PI3K genes have been described to increase the risks for ASD. However, the function of these proteins in the brain and their role in ASD are largely unknown. ESR7 will: characterize the interactions between PTEN and PI3K mutations and the mTOR pathway in neurons at the molecular and cell morphological level; perform behavioural phenotyping of transgenic mouse models of PTEN and PI3K mutations found in the patient cohorts behavioural and cognitive tests in patient cohorts; use functional ultrasound to investigate brain-wide activity in one of the mouse models.

Host: Erasmus University Medical Center Rottedam (ErasmusMC), NL.

Supervisor: Dr. Aleksandra Badura.

Doctoral programme: Erasmus University (4 years PhD Programme).

Envisioned secondments: UCAM, UCL.

 

 

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