PIPGEN - PhD Project 9: Mechanical stress & signal integration by PI3Ks for the control of tumour growth.
Research · Institut national de la santé et de la recherche > France
RESEARCH PROFILE: First Stage Researcher (R1)
APPLICATION DEADLINE: 27 June 2021
EU RESEARCH FRAMEWORK PROGRAME: HORIZON 2020
MARIE SKOLODOWSKA CURIE GRANT AGREEMENT NUMBER: 955534
 First Stage Researcher (R1) PhD candidate or equivalent. Early stage researcher with less than 4 years FTE research experience.
PhD Project details
Approaching mechanical properties of tumours appear as a novel means to treat cancer. PI3K signalling is increased in more than 50% of cancer patients, how PI3K integrates mechanical signal and whether its inhibition could have an impact on the efficiency of these novel strategies is unknown. ESR9 will: establish an in vitro patient or murine organoid model that mimic mechanical stress (compression, tension, shear) and genetic heterogeneity found in pancreatic cancer, map how PI3K activity influences response to mechanical stress in various genetic environments and determine the mechanosensitive determinants that prevent cell growth & migration, validate the most efficient approach in preclinical settings.
Host: Institut national de la santé et de la recherche / Université de Toulouse III (INSERM), France.
Supervisors: Dr. Julie Guillermet-Guibert.
Doctoral programme: Université Toulouse III – Paul Sabatier.
Envisioned secondments: Josep Carreras Institute, U-Paris.