PIPGEN - PhD Project 10: (poly)Genic alterations which emerge from monogenic PTEN-loss driven prostate cancer.

PIPGEN - PhD Project 10: (poly)Genic alterations which emerge from monogenic PTEN-loss driven prostate cancer.

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RESEARCH PROFILE: First Stage Researcher (R1[1])

APPLICATION DEADLINE: 27 June 2021

EU RESEARCH FRAMEWORK PROGRAME: HORIZON 2020

MARIE SKOLODOWSKA CURIE GRANT AGREEMENT NUMBER: 955534

[1] First Stage Researcher (R1) PhD candidate or equivalent. Early stage researcher with less than 4 years FTE research experience.

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PhD Project details

 

Prostate tumours are associated to the process of aging and lifestyle, which could relate to the progressive accumulation of mutations or to the decline of systemic antitumoral capacity. ESR10 will characterise in a PTEN loss-driven mouse model, the impact of aging and lifestyle factors in the susceptibility to develop prostate lesions and we will combine this information with data derived from human prostate cancer specimens. We will perform molecular characterisation of the tumour and stromal component, seeking to define key drivers of the tumorigenic process that can be mechanistically deconstructed. We will capitalize on human prostate cancer multi-omics datasets to determine the clinical relevance of the drivers derived from the mouse model. It is intended that ESR10 will have a predominant training in computational biology, complemented with cellular and molecular biology (gene editing technologies that enable us to alter the prostate genetic makeup based on the findings derived from monogenic disease that will be produced in PIPgen). This project has the impact to provide new research tools to the field while generating key knowledge that can be critical for prostate cancer management.

Host: CIC bioGUNE (cic-BIO), Spain.

Supervisors: Dr. Arkaitz Carracedo and Isabel Mendizabal.

Doctoral programme: Universidad País Vasco.

Envisioned secondments: qGenomics, Inserm.

 

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